THOR Photobiomodulation Therapy Products & Training

It must gall to have performed a controlled clinical trial for a year only to find at the end that your physics department had adjusted the active laser such that it did not perform as planned.

The trial by Tumilty et al (TITLE: Clinical effectiveness of low-level laser therapy as an adjunct to eccentric exercise for the treatment of Achilles’ tendinopathy: a randomized controlled trial) set out to deliver twelve treatments of 100mW/cm2 of 810nm laser for 30 seconds to 6 points (3J per point) on the Achilles tendon over a 4 week period, but something went wrong and the treatment failed to have any significant effect over placebo.

What went wrong: The university physics dept had been asked to adjust the 810nm 100mW, 2.5W/cm2 power density to 100mW/cm2. They achieved the 100mW/cm2 by expanding the beam, but unfortunately they also decided to reduce the aperture to 0.07cm2. This had two unfortunate effects, the 100mW beam became reduced to 7mW and the beam did not adequately cover the pathology. So only 0.21J was delivered and only a tiny part of the pathology was treated.

WALT guidelines say 2-3 points should be treated with 8 Joules, the beam power density should not exceed 100mW/cm2 and irradiation should cover most of the pathological tissue. So this trial was a long way short of the recommended energy and it did not adequately cover the pathology.

Unfortunately these errors are hard to find in the paper. The “method’ reported states that the laser was 100mW, the power density was 100mW/cm2, treatment time was 30 seconds, giving a dose of 3J per point. It is only late in the “discussion” that the errors are presented.

Throughout the paper it is implied that the correct parameters were used and the WALT Guidelines were adhered to, but that is not true. It is not apparent in the paper that the tube had a cap at the end and that it had a 0.07cm2 hole drilled in it. Our initial presumption was that he tube was an empty tube, it was only after correspondence with the authors that we learned these extra facts.

What worries me is that this trial will be used in systematic reviews or as evidence against LLLT or the WALT guidelines

Don’t make these mistakes on your patients or in research, register for a THOR training course and learn about parameters, dose calculations and treatment methods, especially if you intend to run a clinical trial and maybe contact me to help get your trial parameters right,

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I had a meeting with the Chief Exec of the UK’s premier cancer research hospital, last year. He was genuinely interested by my pitch about LLLT. He said I should meet his pain team to present data on Oral Mucositis (OM). Eventually a meeting was set and I gave my best to the Head of Pain Services. Lets call him Dr Fred. Dr Fred listened patiently then, when I had finished, he gave me some feedback: 1) he did not like the company logo 2) he accepts the mechanism of action but 3) LLLT achieves too many things and 4) he had to go to another meeting. A surgeon friend of mine offered to go persuade Dr Fred and they had two hour meeting. Dr Fred said he would pitch it to his team, but after a few weeks chasing for an update, he said that nobody was interested.

How can that be when (according to the article in this months literature watch by Rene-Jean Bensadoun and Raj Nair) there is no consensus on a single agent or agents that can be used either prophylactically or therapeutically to reduce severity or duration of oral mucositis, and yet four associations/agencies* either suggest or recommend LLLT for OM.

Could it be the case that they did not discover LLLT for OM so they are not interested? The good news is that there are three cancer hospitals in three different countries coordinating to run a multi centred trial with THOR lasers so maybe then we can get some interest.

* European Society for Medical Oncology, Multinational Association of Supportive Care in Cancer, International Society of Oral Oncology, U.S. Dept of Health and Human Services Agency for Healthcare Research and quality.

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