Category Archives: Research

40 LLLT papers for you this month including an updated biphasic dose response paper from Mike Hamblin’s team at Harvard (including myself), plus clinical trials on lymphoedema (manual lymphatic drainage vs LLLT), oral mucositis literature review with meta-analysis, onychomycosis, improved treadmill training performance, improved orthodontic tooth movement (with less pain), TMJD, post extraction trismus, and a systematic review of treatments for frozen shoulder citing laser as effective for pain relief, improved range of motion, and overall outcome in adhesive capsulitis.

Just 9 papers for you this month including LLLT for orthodontic tooth movement, diabetic periodontitis, ischemic stroke and a laboratory study on chronic mild stress to add to the clinical reports we have seen in recent months.

A plug for the 2012 World Association for Laser Therapy conference in Gold Coast Australia in September. You know you have to go to Australia at some time in your life, well this is that time. Not only does Australia have the most extraordinary wilderness, wildlife and waves of anywhere in the world, it is also the host of this year’s WALT conference. I anticipate that most of the researchers you have read about on this newsletter / blog over recent years will be there . At the WALT 2012 conference in September you can see their latest work and hear their latest thoughts first hand. This land of sun, sea and and so many lasers is probably the most welcoming country i have ever visited, so I suggest you click here to register and click … Continue reading →

17 papers published this month including LLLT for amblyopia, chronic periodontitis, knee osteoarthritis, cracked nipples in breastfeeding mothers, chronic gingivitis, allergic rhinitis and an editorial written by Prof. Jan Bjordal regarding WALT dosage recommendations. He describes how far we have come and the importance of the WALT dosage recommendations. No abstract is available for editorials so I have prepared one for you along with a short feature on Prof. Jan Bjordal and a summary of his published work.

Low Level Laser Therapy (LLLT) and WALT Dosage Recommendations

No abstract is available for editorials so I have prepared one for you along with a short feature on Prof. Jan Bjordal and a summary of his published work. click here.

Low-Level Laser Therapy Improves Visual Acuity in Adolescent and Adult Patients with Amblyopia.

Ivandic BT, Ivandic T

1 University of Heidelberg , Otto-Meyerhof Center, Heidelberg, Germany .

Abstract Objective: The purpose of this study was to examine the effects of low-level laser therapy (LLLT) on visual acuity in adolescent and adult patients with amblyopia. Background data: Currently, amblyopia can … Continue reading →

22 new papers for your review: RCT on OA knee; systematic review of treatment modalities for neurosensory deficit after lower third molar surgery found LLLT to provide significant improvement; review of transcranial LLLT for neurodegenerative diseases, laser biomodulation of normal and neoplastic cells (another comprehensive study by Farouk Al-Watban with very interesting results); Laser vs LED study on skin flap viability, angiogenesis and mast cells (spoiler alert, LED wins); treatment of dermatitis in 10 koi carp with 980nm laser!; and yet another case of LLLT for burning mouth syndrome.

As it happens, a customer wrote just a minute ago to say that his patient had rapid resolution of burning mouth that lasted 18 hours after the first LED treatment.

Efficacy of low level laser therapy associated with exercises in knee osteoarthritis: a randomized double-blind study.

Alfredo PP, Bjordal JM, Dreyer SH, Meneses SR, Zaguetti G, Ovanessian V, Fukuda TY, Junior WS, Martins RA, Casarotto RA, Marques AP

Department of Speech Therapy, Physical Therapy and Occupational Therapy, School of Medicine, Sao Paulo … Continue reading →

21 new LLLT papers for your review this month including:

– How to report LLLT beam & dose parameters
– Bisphosphonate osteonecrosis of the jaw (BRONJ)
– Rotator cuff tendinitis
– The effect of LED on a patient in a persistent vegetative state
– Two papers on herpes simplex
– A study on acneiform rash due to EGFRI
– LLLT for “coronally advanced flap adjunct” (a gingival surgical
procedure)
– Lymphedema Praecox

How to Report Low-Level Laser Therapy (LLLT)/Photomedicine Dose and Beam Parameters in Clinical and Laboratory Studies.

Jenkins PA, Carroll JD

1 SpectraMedics Pty Ltd , Oakbank, SA, Australia ; SpectraVET Inc., Irradia LLC, and Irradia Education Inc., Lawndale, North Carolina; and Immunophotonics Inc., Columbia, Missouri. 2 THOR Photomedicine Ltd, Chesham, United Kingdom

Background: Dose and beam parameters are critical for successful laser, LED, and other light therapy treatments, however, in our experience, researchers frequently make critical errors and omissions when submitting papers for publication. Journals frequently publish studies with … Continue reading →

28 new LLLT papers for your review this month, including three from the Hamblin stable at Harvard. First on this list (and one I co-authored) is an invited paper called the “The Nuts and Bolts of Low-level Laser (Light) Therapy“. It’s everything you need to know about the latest thinking on the mechanism of action, beam parameters, dose and where the research is going. Next from the Hamblin lab is a dose response study on cortical neurones and, guess what, once again: less is more. 810nm light (25 mW/cm2) on mouse primary cortical neurons induced a significant increase in calcium, ATP and MMP at lower fluences but decreased them at higher fluences. A beautiful biphasic dose response curve shows that increasing the dose beyond  a certain point (3J/cm2 in this case) showed a decline from the peak effect at 10 and 30J/cm2. The third paper in today’s Hamblin trio compares pulsed and continuous wave 810-nm laser for traumatic brain injury in mice with significant benefits of 10Hz over 100Hz or CW. Whilst on … Continue reading →

15 new research papers for you this month including LLLT treatments for: osteonecrosis of the jaw in cancer patients, laser vs ultrasound for shoulder myofascial pain syndrome, radiation-induced mucositis in head and neck cancer patients, persistent idiopathic facial pain and a negative study for subacromial impingement syndrome. This negative result is hardly a surprise as the laser was only 6mW. It is a shame the authors did not come on our training course before embarking on this study. There are ten more papers to review including Alzheimer’s disease, TMJ, respiratory diseases in children and a a MUST READ editorial on the effect of LLLT on suppression of activity of peripheral nerve endings by Dr Roberta Chow MD PhD.

Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: A preliminary study.

Martins MA, Martins MD, Lascala CA, Curi MM, Migliorati CA, Tenis CA, Marques MM

School of Dentistry, Universidade de Sao Paulo, Sao Paulo, SP, Brazil; Department of Oral Pathology, School of Dentistry, Universidade Federal do Rio Grande … Continue reading →