Category Archives: Research

LLLT / Photobiomodulation cures acute thrombocytopenia in mice

Zhang et al showed that whole body 810nm laser 100mW/cm2, 30J/cm2 cures acute thrombocytopenia in mice.

Thrombocytopenia is a common hematologic disorder that is managed primarily by platelet transfusions. They showed that noninvasive whole-body illumination cures acute thrombocytopenia triggered by g-irradiation within 2 weeks in mice, as opposed to a 5-week recovery time required in controls.

The low-level laser (LLL) also greatly accelerated platelet regeneration in the presence of anti-CD41 antibody that binds and depletes platelets, and prevented a severe drop in platelet count caused by a common chemo-therapeutic drug.

They conclude: this safe, drug-free, donor-independent modality represents a paradigm shift in the prophylaxis and treatment of thrombocytopenia.

Full abstract and paper here http://stm.sciencemag.org/content/8/349/349ra101

As you know we are investigating the many possible benefits of whole body treatment PBM with our NovoTHOR light pod novoTHOR.com

NovoTHOR: The whole-body light pod using Photobiomodulation Therapy

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Laser Treatment Halts Oral Mucositis in Its Tracks

Published article by Fran Lowry on Medscape. May 01, 2015.

Spa-like treatment with a cool, low-level laser, similar to that use for wrinkles, vanquishes oral mucositis, one of the most debilitating toxicities of cancer therapy.

“I have been an oncology nurse for over 25 years, and in those 25 years, there has been nothing that helps prevent or is effective against the treatment for oral mucositis, until now,” said Annette Quinn, RN, MSN, from the University of Pittsburgh Cancer Institute.

“Patients say they rank it higher than nausea and vomiting when it comes to adverse side effects, especially because we have good medications to control nausea and vomiting. But the low-level laser works better than we could have hoped,” Quinn told Medscape Medical News.

Read full article from Source: Laser Treatment Halts Oral Mucositis in Its Tracks
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Low-Level Laser Therapy Reduces the Incidence and Severity of Oral Mucositis | PracticeUpdate

Nurse personal experience + 32 trials (1505 patients) treated with LLLT for Oral mucositis presented at Oncology Nursing conference, read full article on PracticeUpdate.

April 23, 2015–Orlando, Florida–Low-level laser therapy has been shown to reduce the incidence and severity of oral mucositis significantly in patients undergoing chemoradiotherapy for head and neck cancer or stem cell transplantation. This result of an analysis of 32 prospective trials including 1505 patients was presented at the 40th Annual Oncology Nursing Symposium from April 23 – 26 in Orlando, Florida.

Annette Quinn, RN, MSN, of the University of Pittsburgh Cancer Institute, explained that oral mucositis is one of the most debilitating toxicities of cancer therapy. Nearly all patients with head and neck tumors treated with chemoradiotherapy, and 75% of those undergoing stem cell transplantation with total body irradiation experience some degree of oral mucositis. “Over the last decade,” said Ms. Quinn, “the prevalence of oral mucositis has risen due to new chemotherapy, the introduction of targeted agents, and the delivery of higher doses of radiation.”

Source: Low-Level … Continue reading

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Masters graduate found LED therapy had positive effect on muscular performance

Tom Hemmings, a Masters graduate student at Georgia Southern University

Great news, Tom Hemmings, a Masters graduate student at Georgia Southern University, found that LED therapy had a positive effect on muscular performance. THOR helped Tom decide on a thesis topic in December 2013, which he completed this past week.

The study itself identified the effects of various dosages of LED on the total repetitions performed during an eccentric leg extension. The dosages of 60 seconds and 120 seconds on each point were found to significantly increase repetitions when compared with the placebo trial.

This study suggests that LED can enhance muscular performance when applying the THOR laser prior an exercise bout.

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Literature watch update: End 2014

130 new LLLT papers for you including a systematic review on shoulder tendinopathies, a lovely article review in an orthopaedics journal by Howard Cotler, four systematic reviews on orthodontic tooth movement, a trial showing LEDs improve sperm motility, another systematic review on oral mucositis and much more.

The Efficacy of Low-Level Laser Therapy for Shoulder Tendinopathy: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Haslerud S, Magnussen LH, Joensen J, Lopes-Martins RA, Bjordal JM

Centre for Evidence Based Practice, Faculty of Health and Social Sciences, NorPhyPain Research Group, Bergen University College, Bergen, Norway; Department of Global Public Health and Primary Care, Physiotherapy Research Group, University of Bergen, Bergen, Norway.

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THOR Literature watch January – May 2014

173 new LLLT papers for you this month. The big news is that “laser regenerates teeth” (details here) and that LED improves symptoms in chronic Traumatic Brain Injury patients (details here).  There is my latest paper on LLLT in dentistry, an LED vs Laser study on oral mucostits and a cost effectiveness study for OM, laser vs corticosteroid for subacromial impingement syndrome, LLLT reduction of postoperative complications Post Myocardial Revascularization, a single case report on LLLT for retinitis pigmentosa, an RCT on carpal tunnel syndrome, a multicentre RCT on Male and Female Pattern Hair Loss, a study on the effect of LED on resorption during orthodontic treatment, a systematic review of LLLT for accelerating tooth movement during orthodontic treatment, the effect of LED on implant stability, LLLT treatment of Chronic Plantar Fasciitis, a TMJ RCT, a wrist fracture RCT, … Continue reading

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Transcranial LLLT for Chronic mild Traumatic Brain Injury

The VA, Boston University and Harvard Medical School published the results of a Transcranial LLLT (LED) pilot study on mild Traumatic Brain Injury (TBI). Incredibly; TBI is a leading cause of death and disability among children and young adults in the United States. Each year an estimated 1.5 million Americans sustain a TBI, 50,000 people die as a consequence, 230,000 are hospitalized and an estimated 5.3 million currently live with a permanent TBI-related disability (because there is no cure). This study showed significant improvement in Executive Function, Verbal Learning, Long Delay Free Recall and fewer post-traumatic stress disorder (PTSD) symptoms. Participants and family reported better ability to perform social, interpersonal, and occupational functions. This was a small pilot study on just eleven patients with chronic mTBI, there was no placebo control group so further studies are necessary to truly establish the effect size.

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