THE SCIENCE BEHIND LLLT
From molecular biology to cell and tissue level-
what are the mechanisms of action?
Text from the official conference flyer:
Over the past 40 years there have been many seemingly extraordinary claims of successful treatments of a wide range of diseases, dysfunctions and injuries through the use of “low-level” laser (or light) therapy (LLLT). Many diﬀerent terms have been used – from LLLT to “biostimulation,” “photobiomodulation,” and other terms. Claims ranging from wound healing, analgesia, reduction of inﬂammation and nerve regeneration have been seriously questioned by the
scientiﬁc community and met with great skepticism by much of the medical community. Since irradiances are below levels that produce any signiﬁcant increase in tissue temperature, it is generally agreed that if these photobiological treatments are real, then they are photochemical rather than photothermal in nature. Although there are now FDA-cleared LLLT treatments and growing acceptance from some quarters, the scientiﬁc acceptance has been routinely set back by poorly designed, less-than-rigorous experimental and clinical studies. Clearly presented photobiological dosimetry and recognition of fundamental methodology in the ﬁeld of photobiology have frequently been lacking. The aim of this ASP symposium is to explore the scientiﬁc evidence for the photobiological mechanisms behind LLLT from molecular biology to cell and tissue level, and to review those clinical results that appear to be well founded. Ample time has been planned for discussion after each review of the key scientiﬁc questions from action spectra to temporal and spatial factors that appear to inﬂuence outcome.
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