As we know, one of the first responses to LED and Laser light absorption is release of or production of Nitric Oxide (NO) and that this reactive molecule modulates a cascade of secondary biological responses ultimately resulting in cytoprotection and/or gross physiological change, (particularly in stressed / hypoxic tissues).
In the current issue of J Molec Cell Cardiol, Zhang and colleagues utilize cultured cardiomyocytes subjected to hypoxia and reoxygenation to demonstrate that 5 min of NIR treatment upon reoxygenation protects the cells from injury and eventual death and that this cytoprotection is dependent on the release of nitric oxide.
but how? read on
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