Monthly Archives: November 2011

Low Level Laser Therapy LLLT / Cold Laser Literature watch for Oct 2011

Posted on 8 November 2011 by James Carroll

28 new LLLT papers for your review this month, including three from the Hamblin stable at Harvard. First on this list (and one I co-authored) is an invited paper called the “The Nuts and Bolts of Low-level Laser (Light) Therapy“. It’s everything you need to know about the latest thinking on the mechanism of action, beam parameters, dose and where the research is going. Next from the Hamblin lab is a dose response study on cortical neurones and, guess what, once again: less is more. 810nm light (25 mW/cm2) on mouse primary cortical neurons induced a significant increase in calcium, ATP and MMP at lower fluences but decreased them at higher fluences. A beautiful biphasic dose response curve shows that increasing the dose beyond  a certain point (3J/cm2 in this case) showed a decline from the peak effect at 10 and 30J/cm2. The third paper in today’s Hamblin trio compares pulsed and continuous wave 810-nm laser for traumatic brain injury in mice with significant benefits of 10Hz over 100Hz or CW. Whilst on … Continue reading →

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Prof. Micheal Hamblin Harvard Medical School

Posted on 8 November 2011 by James Carroll

Low Level Laser Therapy (LLLT) mechanisms and dose response.

Posted in Interviews, Video of the Week | on Prof. Micheal Hamblin Harvard Medical School

LLLT and TRPV1

Posted on 8 November 2011 by James Carroll

TRPV1 is a nonselective cation channel involved in nociception. At a pain conference in London I attended last week a speaker reported that about $ billion has been spent by the pharmaceutical industry on developing a new class of analgesics to block this protein. However there is a sided effect on body temperature (hyperthermia) making it unusable which is a shame as the potential benefits are huge read here on Wikipedia.

TRPV1 is new to me and I wondered if perhaps anyone had looked at the effect of LLLT on it and they have. A group in Korea have shown that Er,Cr:YSGG laser has an analgesic effect via TRPV1 inhibition. Well hooray for the Koreans, if they really have discovered Inhibition of TRPV1 with laser (and without hyperthermia), it could become another medical holy grail assailed by LLLT.

Posted in Rants | 5 Comments