Monthly Archives: December 2008

LOW LEVEL LASER / PHOTOBIOMODULATION DOSIMETRY. WHAT ARE THE THRESHOLDS AND WHAT ARE THE LIMITS?

Posted on 9 December 2008 by James Carroll

James D Carroll FRSM, AMInstP, THOR Photomedicine Ltd, United Kingdom

Photobiomodulation includes biostimulation and bioinhibition. In vitro, in vivo and clinical studies have established that there are radiant intensities and energy thresholds below which no significant cellular stimulation or clinical effects are achieved.  Conversely there are radiant intensities and total fluence thresholds above which cellular stimulation decreases from its peak effect and inhibition is achieved. Many dose-ranging studies have been published using a variety of laboratory and clinical models and most suggest that cellular stimulation is achieved at radiant intensities in the range of 5 – 50mW/cm2 (at the target tissue ) and that exceeding these levels can inhibit cellular function.

So what is the role of the higher intensity laser products that appear to be popular with some clinicians and their patients ?

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LED Phototherapy kills MRSA @ 405nm

Posted on 8 December 2008 by James Carroll

Congratulations to Chukuka et al for taking the inititive to do this work. The outcomes of this high “dose” / short wavelenght invitro study come as no surprise as this effect has been forecast for some time. For decades that UV light has bactericidal effects but that it can also have carcinogenic effects. 405nm is blue light (just outside the range) so should should be a safer option.

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